![]() When a lotus flower reaches up from underwater and into the light, it is the same as spiritual awakening and enlightenment for humans. The lotus flower design in mandalas usually depicts balance and is a sacred symbol in Buddhism. When you have put all the colors in this image, it will surely give a sense of peace and harmony. The layers of this flower are arranged in a balanced way that is pleasing to the eyes. This first mandala printable is a geometric lotus flower design arranged inside a circle. 10 Brand New Mandala Coloring Pages – Free to Print and Color Get your coloring tools out as it is time to enjoy these 10 free mandala printables. More than its appearance, a mandala holds much meaning to different people.īecause of its detailed look and design and the deep meaning behind it, we created mandala coloring pages that you can download and print for free. The circular design of a mandala represents the idea of life never-ending and that everything in this world is connected. In their most basic form, mandalas are usually shaped circles with various shapes or designs arranged in a very organized way around a central focal point. It’s famous globally because of its powerful significance to various religions and traditions as well as its distinct and vibrant appearance. ![]() Mandala is an extraordinary work of art with intricate geometric designs that hold spiritual and symbolic meaning. ![]()
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![]() ![]() ![]() Įvgeny Fesenko, Stanislav Kolesnikov, and Arkady Lyubarsky discovered in 1985 that cyclic guanosine monophosphate (cGMP) can initiate the photoresponse in rods. Further, it was proved that this factor reverted to 5’-AMP when it was inactivated. The “active factor” that the hormones produced was finally purified in 1958, and then identified as containing a ribose, a phosphate, and an adenine in equal ratios. While investigating the action of adrenaline on glycogenolysis the next year, Sutherland and Walter Wosilait reported that inorganic phosphate is released when the enzyme liver phosphorylase is inactivated but when it is activated, it incorporates a phosphate. In 1956 Edwin Krebs and Edmond Fischer discovered that adenosine triphosphate (ATP) is required for the conversion of glycogen phosphorylase b to glycogen phosphorylase a. Earl Sutherland investigated the effect of the hormones adrenaline and glucagon on glycogen phosphorylase, earning him the Nobel Prize in Physiology or Medicine in 1971. Glycogen phosphorylase catalyzes the first step in glycogenolysis, the process of breaking glycogen into its substituent glucose parts. A number of incremental but important discoveries through the 1950s added to their research, primarily focusing on the activity of glycogen phosphorylase in dog liver. The understanding of the concept of second messengers, and in particular the role of cyclic nucleotides and their ability to relay physiological signals to a cell, has its origins in the research of glycogen metabolism by Carl and Gerty Cori, for which they were awarded a Nobel Prize in Physiology or Medicine in 1947. Although more than 50 years have passed since their initial discovery, interest in cyclic nucleotides and their biochemical and physiological significance continues. The role of cyclic uridine monophosphate (cUMP) is even less well known.ĭiscovery of cyclic nucleotides has contributed greatly to the understanding of kinase and phosphatase mechanisms, as well as protein regulation in general. cAMP and cGMP are currently the most well documented cyclic nucleotides, however there is evidence that cCMP (with cytosine) is also involved in eukaryotic cellular messaging. They have been identified as secondary messengers in both hormone and ion-channel signalling in eukaryotic cells, as well as allosteric effector compounds of DNA binding proteins in prokaryotic cells. Their biological significance includes a broad range of protein- ligand interactions. As can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic' portion consists of two bonds between the phosphate group and the 3' and 5' hydroxyl groups of the sugar, very often a ribose. Like other nucleotides, cyclic nucleotides are composed of three functional groups: a sugar, a nitrogenous base, and a single phosphate group. The cyclic portion refers to the two single bonds between the phosphate group and the riboseĪ cyclic nucleotide (cNMP) is a single- phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. 1 It also serves as an extracellular morphogen for some slime moulds.Cyclic nucleic acid Cyclic adenosine monophosphate. In bacteria, cAMP is involved in the positive regulation of bacterial lac operon in association with the culture medium used for bacterial growth. Its activation of calcium channels gives rise to a minor pathway through which growth hormone-releasing hormone facilitates the release of growth hormones. 1Īpart from the intracellular signal transduction with certain kinases, cAMP has also a role in the regulation of the passage of calcium ions through ion channels. ![]() For instance, protein kinase C is not cAMP-dependent. Not all protein kinases though respond to cAMP. phosphorylate) specific proteins bound to the promoter regions of DNA, and thereby further enhance transcription. Upon phosphorylation, the protein substrates may act on the ion channels or they may become inhibited. The catalytic sub-unit may act on certain protein substrates, transferring phosphate to the latters’ serine or threonine residues. ![]() cAMP binds at the regulatory sub-units of the protein kinase, which leads to the dissociation of the latter into regulatory and catalytic sub-units. It works by activating protein kinase A (PKA). These hormones cannot pass through the plasma membrane of target cells and therefore need cAMP as a second messenger. In particular, it is used in transferring into cells the effects of glucagon and adrenaline. It is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. CAMP serves as a second messenger for signal transduction at the cellular level. ![]() ![]() ![]() However, in Cmdline mode, entering a command exits the mode when the command is executed. Ex mode - similarly to Cmdline mode, it takes a single line input at the bottom of the window.Normal commands (beginning with :), and some other specific letters corresponding to different actions (including pattern search and the filter command) activate this mode. Command-line or Cmdline mode - supports a single line input at the bottom of the Vim window.In insert mode, buffers can be modified with the text inserted. Insert mode - similar to editing in most modern editors.However, if a printable character, carriage return, or newline (or line feed) is entered, Vim inserts the character, and starts insert mode. Select mode - works similarly to visual mode.Normal commands are run on the highlighted area, which for an instance can be used to move or edit a selection. Visual mode - similar to normal mode, but used to highlight areas of text.This is also the default mode, unless the insertmode option is specified. ![]() Normal mode - used for editor commands.Vim has 12 different editing modes, 6 of which are variants of the 6 basic modes. Terminal window support and terminal gdb plugin. Lua support, Python3 support, Blowfish encryption, persistent undo/redoĪsynchronous I/O support, jobs, lambdas, etc. Spell checking, code completion, tab pages (multiple viewports/window layouts), current line and column highlighting, undo branches, and moreīug fixes, new syntax and runtime files, etc.įloating point support in scripts, refactored screen drawing code, bug fixes, new syntax files, etc. GTK2 and libgnome2 support, Arabic language support, :try command, minor features, bug fixesīug fixes, translation updates, mark improvementsīug fixes, updates to Perl, Python, and Ruby support Long line support, file browser, dialogs, popup menu, select mode, session files, user defined functions and commands, Tcl interface, etc.īasic file encryption, various improvements Syntax highlighting, basic scripting (user defined functions, commands, etc.) ![]() This is the first release using the name Vi IMproved. īram Moolenaar creates Vi IMitation for the Amiga, based on Stevie, never publicly releasedįirst public release for the Amiga on Fred Fish disk #591 Tony Andrews improves Stevie, and ports it to Unix and OS/2, releasing version 3.10 on Usenet. Tim Thompson releases Stevie (ST editor for VI enthusiasts), a limited vi clone for the Atari ST, posting the source on Usenet. vimrc, you’ll paste all your custom config at this file.At the time of its first release, the name 'Vim' was an acronym for 'Vi IMitation', but this changed to 'Vi IMproved' in 1992. If you’re coming from vim like me, you can simply type :help nvim-from-vim and follow the instructions, simplifying is just create a file ~/.config/nvim/init.vim that will be like your. The next question of everybody is probably “Ok, but I’ll need to configure everything again? All my plugins?” and the answer is No, you won’t. You can download neovim in the following two sites:Īs I described I choose the appimage, so I just downloaded and moved it to /usr/local/bin and all works fine, now just type nvim and it will open. The first thing that I loved is the facility on download, at the official repository they provide a lot of good options for each OS, for Linux, an appimage file and that is awesome, for who doesn’t know it is like MAC OS applications file, for MAC OS you can download using brew and for windows you can download using chocolatey. ![]() ![]() ![]() All 16 tracks are great and the mix is fine. Bobby Rush: Live at Ground Zero (2007 Video) Full Cast & Crew See agents for this cast & crew on IMDbPro Directed by Jef Judin Cast Produced by Music by Bro Paul Brown. Special guests are: Mr Jimbo Mathus Electric Slide guitar TRACKS 5,6,7 Mr. ![]() Any fan of Rush''s unique brand of sweaty soul-blues will find great satisfaction in this live DVD. Watermelon Slim and the Workers put on a great show at Ground Zero Blues Club in Clarksdale. The live music will leave you swaying in your seat. Due to the current limited nature of music titles and production issues, ALL CD & Vinyl. Hes also released a live CD/DVD called Ground Zero, which was recorded at the. Bobby Rush is coming to Ground Zero Blues Club Biloxi in Biloxi on Feb 17, 2023. Bobby Rush- Live At Ground Zero Blues Club - Darkside Records. Legend Bobby Rush on Stage at Morgan Freeman's Club Ground Zero in. Blues legend Bobby Rush strolls, shakes into town Bobby Rush has been a. He''s also been the subject of a documentary titled The Road To Memphis, Richard Pearces film in the PBS series Martin Scorseses The Blues. Chitlin Circuit Show headliner Bobby Rush brings his sweaty brand of soul-blues to the Ground Zero Blues Club, and now fans can enjoy this blistering. 'Actor Morgan Freeman joins Blues Artist Mizz Lowe and Grammy. At a time when most of his contemporaries are resting on their laurels, Bobby Rush-a 50-year veteran of the stage-continues to be one of the most exciting and creative artists in the R&B/blues arena.įor decades, his provocative and colorful Chitlin Circuit show has been a staple in the black community as well as a cult sensation in alternative circles. Find many great new & used options and get the best deals for Bobby Rush - Live at Ground Zero Blues Club New DVD at the best online prices at eBay Free shipping for many products Skip to main content. ![]() ![]() The coil is moving parallel to the direction of the magnetic field, so no potential difference is induced. Here, the induced potential difference travels in the same direction as at B.Ī - The coil is at 360°, ie it is back at its starting point, having done a full rotation. The Marshall Cavendish Education Cambridge IGCSE. Please see links at the bottom of the page. These MME Physics revision cards cover all the major topics within the AQA GCSE Physics specification. Please note this title is suitable for any student studying: Exam Board: AQA Level: GCSE Subject: Physics First teaching: September 2016 First exams: June 2018 The UK's bestselling GCSE Science series has now been updated and specifically tailored for the new 2016 AQA GCSE Science (9-1) specifications. These booklets are free to download I hope they are useful. We do AQA Trilogy but most of the KS4 content is applicable for all boards. The coil is moving at 90° to the direction of the magnetic field, so the induced potential difference is at its maximum. Welcome to my page for new and improved SLOP booklets for Physics GCSE. The coil is moving parallel to the direction of the magnetic field, so no potential difference is induced.ĭ - The coil is at 270°. The coil is moving at 90° to the direction of the magnetic field, so the induced potential difference is at its maximum.Ĭ - The coil is at 180°. The final question on our GCSE Physics (8463) Higher Tier Paper 1 on Thursday 9 June 2022 was about energy transfers and circuits. The coil is moving parallel to the direction of the magnetic field, so no potential difference is induced.ī - The coil is at 90°. The potential difference-time graph for a dynamoĪ - The coil is at 0°. The diagram shows four different positions of the coil in a dynamo, and the corresponding potential difference produced. increasing the number of turns on the coil.increasing the strength of the magnetic field.The maximum potential difference or current can be increased by: The graph shows a sine curve that stays in the same direction all the time. The output of a rotating dynamo can be shown on a potential difference-time graph. This means that the current to the external circuit always flows in the same direction. As the induced potential difference is about to change direction, the connections are reversed. In a dynamo, a split ring commutator changes the coil connections every half turn. The dynamo In a bike dynamo, the magnet rotates inside a fixed coil of wire Some bike lights use a type of dc generator called a dynamo to run the lamps while the wheels are turning. However, it uses a split ring commutator rather than the two slip rings found in alternating current (ac) generators. ![]() A simple dc generator consists of a coil of wire rotating in a magnetic field. A direct current (dc) generator is another device that produces a potential difference. ![]() ![]() ![]() You can buy many different styles of commercial cannabis hydroponic systems. There are many variations for a hydroponic cannabis grow. This material is exposed to the air, which allows the cannabis roots access to vital oxygen. Some methods used to grow hydroponic cannabis, such as Nutrient Film Technique (NFT), trickle the nutrients over a fabric mat which the roots grow in/through. The nutrient solution is often fizzing with air bubbles from an air stone or air hose, this prevents the roots rotting in the nutrient solution. Naturally people disputed his claims, until he proved them all wrong by growing tomato vines 25 feet (7.6m) tall.Ĭannabis hydroponic nutrients need to be of the correct blend and strength for the particular growth stage of your plants. While working at the University of California, Berkeley, he began to promote the idea that plants could be grown in a solution of nutrients and water instead of soil. The earliest modern reference to hydroponics was by William Frederick Gericke. The plant roots would dip into the lake water to absorb water. The Aztecs grew crops on rafts of soil on Lake Tenochtitlan. The gardens were created by diverting river water into a series of channels in which plants were grown. Back in 600 BCE, the Hanging Gardens of Babylon were famed for their lush and beautiful growth. Hydroponics isn’t an entirely modern invention. When trying to grow cannabis in a hydroponic system the plants may be grown in a bucket or basket with a full tank/container of nutrients for the roots to grow in. Hydroponics is a way of growing cannabis without soil. Learn everything you should know about hydroponics and whether or not it’s for you. Growing hydroponic cannabis indoors is easy if a few basic rules are followed. But others simply wouldn’t grow cannabis any other way. For some people, hydroponic cannabis growing is intimidating, technically demanding and complicated. When using hydroponics, cannabis can grow without soil and typically grows faster than just about any other grow technique. ![]() Hydroponic cannabis growing is a way of growing cannabis using a solution of just water and nutrients. ![]() ![]() ![]() You can now download Sophos Home Premium on up to 10 personal computers, managed by logging in to the Sophos Home website with the Sophos account you created in step 4 (i.e.When you are asked to register, create your Sophos account using your University email address but using a different password to the one you use to log in to University systems.Check your University staff mailbox for the Sophos email with instructions.Enter your University email address-this is to confirm you are an employee of the University, this does not link to your University login credentials.Go to the Sophos Home Commercial Use Edition page.To acquire Sophos Home Premium under the University’s agreement: This is a separate, personal Sophos account, and is not linked to your University username and password credentials, so you will need to create a new password for this account and not use your University password for it. Sophos Home Premium provides further support such as ransomware security, banking privacy and identity protection, a malware removal tool, and more. 15000+ Software, 5500+ Vendors, 600+ Categories, 1+ Lakh Verified Reviews. With free antivirus for Mac, you are taking proactive steps to boost security from Mac-related threats and not worrying about sensitive information on your Mac falling into the wrong hands.The University of Otago has an agreement with Sophos for employees to have access to Sophos Home Premium for free for their personal devices. Techjockey Helps Million of Businesses to Buy the Best Software Online in India. It also blacklists malicious websites, making sure you do not inadvertently connect to them. It then reverts data to a pre-tampered state. Sophos Home Mac antivirus protects your Macs from ransomware by shutting down processes that encrypt personal information. The focus of Sophos Home for Mac is to improve your Mac’s cybersecurity posture with enterprise-grade security that offers comprehensive protection against the widest range of threats, both known and unknown. Protect against viruses & other types of malware with Avast Mobile Security, our free antivirus app for Android. Antivirus protection helps protect your Mac from threats posed by increasing attack surfaces and vectors. Your Mac security should keep in step with rapidly evolving attack vectors such as phishing, identity theft, ransomware, trojans, rootkits and more. The tighter control exercised over the Apple ecosystem makes Macs more secure, but cyberthreats are growing more sophisticated by the day. No Product Key or Serial Required Business-Grade Security Now you have the same level of protection trusted by leading banks, governments, and businesses worldwide. Features full protection for your home network, including anti-malware, web security and URL filtering, application control, IPS, traffic shaping, VPN, reporting and monitoring, and much. Utiliza una combinación de detección basada en firmas y en el comportamiento. Download Sophos Home Free And Premium With 30-Days Trial. Our Free Home Use Firewall is a fully equipped software version of the Sophos Firewall, available at no cost for home users no strings attached. Una cuenta de Sophos puede instalarse en tres dispositivos. Why does your Mac need antivirus protection? Sophos Home Free funciona como antivirus, filtro web y programa de supervisión remota. ![]() ![]() ![]() No – the oxide bond produced by the chromium coats the surgical steel like a film. However, surgical devices designed for use as implants will usually have a lower nickel content, to prevent infection in the patient’s body. ![]() Surgical steel can also contain a higher concentration of Molybendum, to further reduce corrosion, and nickel, which reduces its brittleness. Surgical steel will contain at least 13% chromium, compared to standard stainless steel’s 10.5%. Medical grade stainless steel – that is, surgical steel – tends to have a higher concentration of chromium. Stainless steel comes in a variety of grades. ![]() For while almost all surgical instruments are made from stainless steel, not all stainless steel is suitable for medical use. What Are The Differences Between Surgical Steel and Stainless Steel? And as it’s chemically inert, you can safely sterilise surgical steel with no risk of corrosion or degradation. Surgical steel is also nonporous, making it more hygienic for use in clinical environments. This chromium reacts with oxygen in the air to form a stable oxide bond that helps prevent rust. Surgical steel is a low-carbon steel containing high concentrations of chromium. Finally, we’ll let you know how you should choose the right steel quality for your surgical purposes. We’ll explore how it differs from standard stainless steel, before addressing some of the most commonly asked questions people have about surgical steel. This is your essential guide to surgical steel. The size and the function are important, but just as important is the quality of the steel. You have to be able to rely on your surgical instruments. ![]() ![]() ![]() USIA did not rebuild the tank, and new war technology made the mass distillation of molasses for industrial alcohol obsolete. She hopes the flood taught "people to have some respect for the destructive power of things we usually think of as harmless." In his book, Puleo writes, "Shortly after the flood, the Boston Building Department began requiring that all calculations of engineers and architects be filed with their plans and that stamped drawings be signed." This later became standard practice across the country. Puleo told NBC News that "the tank didn't even require a permit because it was considered a receptacle, not a building," adding, "Every building construction standard that we sort of take for granted today comes about because of the Molasses Flood." Though the flood has been long forgotten in popular memory, its legacy remains. Courtesy of Dark Tide and Boston Fire Department Archives ![]() A week later, with the almost-full tank weighing 26 million pounds and the gas inside putting extra pressure on the steel walls, it ruptured.ĭamage from the Great Boston Molasses Flood in 1919. People reported hearing the tank whining and groaning. Puleo said that seven days before the flood, on a day with a low of 2 degrees Fahrenheit, a new shipment dumped more than half a million gallons of molasses into the poorly built tank.Īs warm molasses from the ship mixed with cold molasses in the tank, it triggered a fermentation process that produced gas. In 1918, in an effort to shield the leaks and avoid costly fixes, Jell even had the steel-colored tank painted brown, to camouflage the oozing molasses. Profits from the war were pouring in as steadily as molasses was leaking out of the tank. "It should have been very straightforward." Building the tank, Mayville explained, is "a relatively simple calculation that most engineers could do in that day."Įven though workers alerted USIA to the leaks, the company remained unperturbed. "The stress in the tank is directly linked to the fluid inside," he said. Mayville analyzed the flood using today's engineering tools and suspects the tank might have been designed for water instead of molasses. ![]() Ronald Mayville, a senior principal at the engineering firm Simpson Gumpertz & Heger in Massachusetts, has studied the molasses flood in his spare time. "The tank starts leaking on Day 1," Puleo said. Instead of filling the entire tank with water after it was finished to test for leaks, he only put in six inches of water. People were trapped, with witnesses described trying to breathe while stuck, gasping for their lives and simultaneously trying to avoid inhaling too much.įrom the beginning, Jell sidestepped safety precautions. As molasses flooded the streets, it slowed but became thicker and stickier, and still difficult to escape. Many survivors had broken backs and fractured skulls.ĭuring the second stage of the flood, "the inertia runs out as the molasses spreads - that's when viscosity starts to matter," Sharp said, referring to a liquid's resistance to flow. People's bones were crushed, their bodies thrown onto buildings and train cars. "When the initial wave came through, it just pulverized everything," Sharp said. When the tank broke and the molasses exploded, there was no outrunning it. The inertia is so much more powerful than the forces that can be moved by the viscosity." "The fact that the molasses is extremely viscous doesn't matter for the first 60-90 seconds. When the tank ruptured, all that potential energy became kinetic energy. The tank, piled so high with molasses, stored a large amount of potential energy. ![]() "Molasses is 1.5 times heavier than water. Sharp said the flood could be broken down into two stages, with the first called "The Tsunami." "I found that the initial wave could have moved at that speed," she said. Sharp decided to look into the science behind the flood, along with a team of scientists at Harvard. ![]() ![]() ![]() In 1985, he was part of the new, younger cast hired for Saturday Night Live, but following a year of poor ratings and criticism of the new cast's comedic talents, he and most of the new crew were dropped and replaced. Career 1983–1995: Early work and critical acclaim Downey at the premiere of Air America in 1990ĭowney began building upon theater roles, including in the short-lived off-Broadway musical American Passion at the Joyce Theater in 1983, produced by Norman Lear. ĭowney and Kiefer Sutherland, who shared the screen in the 1988 drama 1969, were roommates for three years when he first moved to Hollywood to pursue his career in acting. When his parents divorced in 1978, Downey moved to California with his father, but in 1982, he dropped out of Santa Monica High School, and moved back to New York to pursue an acting career full-time. ![]() He attended the Stagedoor Manor Performing Arts Training Center in upstate New York as a teenager. At the age of 10, he was living in England and studied classical ballet as part of a larger curriculum. He made his acting debut at the age of five, playing a sick puppy in the absurdist comedy Pound (1970), and then at seven appeared in the surrealist Western Greaser's Palace (1972). ĭuring his childhood, Downey had minor roles in his father's films. Downey later stated that drug use became an emotional bond between him and his father: "When my dad and I would do drugs together, it was like him trying to express his love for me in the only way he knew how." Eventually, Downey began spending every night abusing alcohol and "making a thousand phone calls in pursuit of drugs". Īs a child, Downey was "surrounded by drugs." His father, a drug addict, allowed Downey to use marijuana at age six, an incident which his father later said he regretted. ![]() He and his older sister Allyson grew up in Greenwich Village. Downey's father was of half Lithuanian Jewish, one-quarter Hungarian Jewish, and one-quarter Irish descent, while Downey's mother had Scottish, German, and Swiss ancestry. His father, Robert Downey Sr., was an actor and filmmaker, while his mother, Elsie Ann (née Ford), was an actress who appeared in Downey Sr.'s films. ![]() was born on April 4, 1965, in Manhattan, New York City, the younger of two children. Downey has also taken on dramatic parts in The Judge (2014) and Oppenheimer (2023). He has also played Sherlock Holmes in Guy Ritchie's Sherlock Holmes (2009), which earned him his second Golden Globe, and its sequel, Sherlock Holmes: A Game of Shadows (2011). He went on to star in the black comedy Kiss Kiss Bang Bang (2005), the thriller Zodiac (2007), and the action comedy Tropic Thunder (2008) for the latter, he was nominated for an Academy Award for Best Supporting Actor.ĭowney gained global recognition for starring as Tony Stark/Iron Man in ten films within the Marvel Cinematic Universe, beginning with Iron Man (2008), and leading up to Avengers: Endgame (2019). Initially, completion bond companies would not insure Downey, until Mel Gibson paid the insurance bond for the 2003 film The Singing Detective. He stayed in a court-ordered drug treatment program and has maintained his sobriety since 2003. He was fired from the show in the wake of drug charges in 20. Following a stint at the Corcoran Substance Abuse Treatment Facility on drug charges, he joined the TV series Ally McBeal, for which he won a Golden Globe Award. In 1992, Downey portrayed Charlie Chaplin in the biopic Chaplin, for which he was nominated for the Academy Award for Best Actor and won a BAFTA Award. He subsequently worked with the Brat Pack in the teen films Weird Science (1985) and Less than Zero (1987). Īt the age of five, he made his acting debut in his father Robert Downey Sr.'s film Pound in 1970. In 2008, Downey was named by Time magazine among the 100 most influential people in the world, and from 2013 to 2015, he was listed by Forbes as Hollywood's highest-paid actor. His career has been characterized by critical and popular success in his youth, followed by a period of substance abuse and legal troubles, before a resurgence of commercial success later in his career. (born April 4, 1965) is an American actor. ![]() |
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